Multiplayer is a mode, in which it allows players to compete with other players. In multiplayer, there are two modes available, the Versus Mode added in December 2015 and the Co-Op Mode added in February 2016.
The multiplayer mode adds special abilities, symptoms and transmissions, which will help players gain more infectivity, severity, lethality or resistance to the cure. It also adds particular genes that help the plague adapt better in certain environments.
VS Mode is a game mode introduced in Evolution 15 for Plague Inc: Evolved released at the end of 2015, which consists of two players competing against each other to see which plague will dominate and end the world.
Co-op mode
This mode is where your two plagues work together to wipe out humanity. If one of your plagues do, then you will both win.
Gameplay
In Co-op mode, two players work together to wipe out humanity. Gameplay has been heavily altered from the main game like in Vs. Mode but with several differences. The player's plague is colored red while the partner's plague is coloured yellow. The population infected by both plagues is orange. The goal is the same for both players.
There are genes exclusive to multiplayer like in Vs, however, they have to be unlocked separately rather than being carried over from VS.
Victory
When both players managed to wipe out the world. Even if one plague is wiped out, by either cure or killing all of it's infected, the other can still win the game for both players as long as they finish the job.
Defeat
When both plagues are wiped out, the game will end in defeat.
Starting Location
Like in Vs. Different starting countries also gives different amount of starting DNA, unlike Vs. Mode, you can see what country your partner has started in and nothing will happen if you infect their country.
Differences from Vs. Mode
You can see what traits your partner has evolved, however, keep in mind that when you evolve one trait, it'll be drastically more expensive for your partner if they also wish to evolve it. Devolving your trait will remove this penalty for your partner.
There are two additional active abilities along with Unscheduled Flight: Infectivity Boost and Lethality Boost. Infectivity Boost like it's namesake, drastically boosts the infectivity in the country(s) you put it in while Lethality Boost will drastically increase the lethality in the country(s) you put it in.
Both players will get bonus DNA as long as their country still has infected people in them.
New to this game are Cure Labs, they are randomly set up in countries and specifically targets the disease that is the bigger threat before the lab is set.
To destroy the labs, you have to kill off the country the lab is located in.
These labs will skyrocket the cure and likely cause one of you to get cured very quickly.
Therefore, it is very important both players get discovered at the same time and spread out their threat level so the world don't just focus on cure one and then the other.
If one player is wiped out, they can still aid their partner by sending them to uninfected countries with Unscheduled Flights, quickly infect a country with the Infectivity Boost ability, kill off a country with the Lethality Boost ability or devolve their previous traits to make them cheaper for their partner. Additionally, the eradicated player will receive DNA regularly.
Genetic Code
Information on gene statistics was directly obtained by extracting text files from the game. See Game Files § Genetic Code
Gene Name
Base Hydration
Description
Your plague can mutate transmissions and abilities but costs to evolve will increase quickly (Can mutate abilities and transmissions but costs escalate by 2 DNA for every tranmission/symptom/ability)
Gene Name
Benign Infection
Description
Your plague is harder to cure but you start the game with less DNA (+0.07 Cure Requirement & -5 Bonus DNA)
Gene Name
Deadly Disinfectant
Description
Your plague will find it easier to kill people infected by other diseases but harder to infect them
Gene Name
Frigophobe
Description
Gives your plague a bonus in hot countries but a penalty in cold countries (+0.10 to hot & -0.16 to cold)
Gene Name
Hydrophobe
Description
Gives your plague a bonus in arid climates but a penalty in humid climates (+1.33 to arid & -1 to humid)
Gene Name
Innocent Infection
Description
Your plague will find it easier to infect people infected by other diseases but harder to kill them
Gene Name
Peekaboo
Description
See which countries your opponent has infected when you find your starting country but gain less DNA when you find it (See countries your opponent has infected, gain less 7 DNA from the yellow bubble)
Gene Name
Pharmaphile
Description
Gives your plague a bonus in wealthy countries but a penalty in poor countries (+0.12 to rich & -0.5 to poor)
Gene Name
Pharmaphobe
Description
Gives your plague a bonus in poor country but a penalty in rich country (+0.5 to poor & -0.12 to rich)
Gene Name
Rurophobe
Description
Gives your plague a bonus in urban environments but a penalty in rural environments (+0.67 to urban & -0.57 to rural)
Gene Name
Safe House
Description
Gain more DNA from bubbles in your starting country but your opponent gets bonus DNA when it is discovered (Gain +2 DNA for every starting country bubble popped, opponent gains +12 DNA for finding your starting country)
Gene Name
Search and Destroy
Description
Gain a DNA from finding your opponents starting country. The bonus decreases the longer it takes. (Gain +25 DNA for finding your opponents starting country, you lose 0.13 DNA for every day you don't find your opponents starting country
Gene Name
Thermophobe
Description
Gives your plague a bonus in cold countries but a penalty in hot countries (+0.16 to cold & -0.10 to hot)
Gene Name
Unstable Inception
Description
Get bonus DNA at the beginning but your starting country will be selected randomly (+8 DNA bonus starting DNA)
Gene Name
Urbophobe
Description
Gives your plague a bonus in rural environments but a penalty in urban environments (+0.57 to rural & -0.67 to urban)
Gene Name
Xerophobe
Description
Gives your plague a bonus in humid climates but a penalty in arid climates (+1 to humid & -1.33 to arid)
Achievements
Achievement Name:
Beta Infection
Achievement Description:
Play a multiplayer VS game to completion with someone who already has the Beta Infection achievement
Value:
Difficulty:
Any
Achievement Name:
Ndemic Infection
Achievement Description:
Play a multiplayer VS game to completion with someone who already has the Ndemic Infection